Article

Single fiber proteomics of respiratory chain defects in mitochondrial disorders

2018-09-20

Abstract excerpt

Mitochondrial DNA mutations progressively compromise the respiratory chain of skeletal muscle, resulting in a mosaic of metabolically healthy and defective fibers. The single fiber investigation of this important diagnostic feature has been beyond the capability of large-scale technologies so far. We used laser capture microdissection (LCM) to excise thin sections of individual muscle fibers from frozen biopsies o...

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Identifiers and source

Literature Corpus work: a351d163-ab01-5044-8d1c-42bce784b9ba
DOI: 10.1101/421750

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