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Article

The phosphoinositide 3-kinase pathway and therapy resistance in cancer

3 Feb 2015

Abstract excerpt

The phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is a master regulator of processes that contribute to tumorigenesis and tumor maintenance. The PI3K pathway also plays a critical role in driving resistance to diverse anti-cancer therapies. This review article focuses on mechanisms by which the PI3K pathway contributes to therapy resistance in cancer, and highlights...

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PMID: 25750731
DOI: 10.12703/p7-13

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