Article
Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2005
Camp E Ramsay, Summy Justin, Bauer Todd W, Liu Wenbiao, Gallick Gary E, Ellis Lee M
Abstract excerpt
Targeted therapies that inhibit the activity of tyrosine kinase receptors such as the epidermal growth factor receptor (EGFR) have shown activity against solid malignancies when used as single agents or in combination with chemotherapy. Although anti-EGFR therapies are active in some patients, eventually disease in nearly all patients will become refractory to therapy. Therefore, a better understanding of the...
Topics
- Carcinoma
- Drug Resistance, Neoplasm
- ErbB Receptors
- Female
- Humans
- Ligands
- Lung Neoplasms
- Male
- Models, Biological
- Mutation
- Neovascularization, Pathologic
- Protein Structure, Tertiary
- Signal Transduction
- Skin Neoplasms