Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type p53 activates SAP expression in lymphoid cells.

Oncogene - 11 Nov 2004

Nagy N, Takahara M, Nishikawa J, Bourdon J C, Kis L L, Klein G, Klein E

Abstract excerpt

SAP is an adaptor molecule with one SH2 domain and it is expressed in activated T and NK cells, where it is required for the appropriate signaling from the SLAM family of surface receptors. Deleted or mutated SAP genes that encode functionally defective protein are associated with the X-linked lymphoproliferative disease (XLP). This primary immunodeficiency is characterized by extreme sensitivity to Epstein-Barr...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Burkitt Lymphoma
Share to Intracellular Signaling Peptides and Proteins
Share to Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phytohemagglutinins

Share to Response Elements

Share to Signaling Lymphocytic Activation Molecule Associated Protein

Share to T-Lymphocytes

Share to Up-Regulation

Source

Identifiers

PMID: 15378026
DOI: 10.1038/sj.onc.1207908

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type p53 activates SAP expression in lymphoid cells.PMID 15378026Read ↗

p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAPSemantic proximity Read ↗

The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative diseaseSemantic proximity Read ↗

SLAM-associated protein deficiency causes imbalanced early signal transduction and blocks downstream activation in T cells from X-linked lymphoproliferative disease patients.Semantic proximity Read ↗

Activation-dependent T cell expression of the X-linked lymphoproliferative disease gene product SLAM-associated protein and its assessment for patient detection.Semantic proximity Read ↗

SAP mediates specific cytotoxic T-cell functions in X-linked lymphoproliferative diseaseSemantic proximity Read ↗

Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP.Semantic proximity Read ↗

Impaired Epstein-Barr virus–specific CD8+ T-cell function in X-linked lymphoproliferative disease is restricted to SLAM family–positive B-cell targetsSemantic proximity Read ↗

Abnormal T cell receptor signal transduction of CD4 Th cells in X-linked lymphoproliferative syndrome.Semantic proximity Read ↗

TULA‐family proteins: A new class of cellular regulatorsSemantic proximity Read ↗

Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition.Semantic proximity Read ↗

Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAPSemantic proximity Read ↗

STAT5A is regulated by DNA damage via the tumor suppressor p53.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.