Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations.

Breast cancer research and treatment - 1 May 2010

Yu Ke-Da, Di Gen-Hong, Li Wen-Feng, Rao Nan-Yan, Fan Lei, Yuan Wen-Tao, Hu Zhen, Wu Jiong, Shen Zhen-Zhou, Huang Wei, Shao Zhi-Ming

Abstract excerpt

Growth arrest and DNA damage-induced 45, alpha (GADD45A) is a candidate breast cancer susceptibility gene because its product participates in DNA repair and it is a downstream gene of p53 and BRCA1, both of which are breast cancer susceptibility genes. We screened germline mutations of GADD45A in 185 non-BRCA1/2 familial breast cancer patients, but no deleterious mutation was found. Seven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Genes, BRCA2

Share to Germ-Line Mutation

Share to Linkage Disequilibrium

Share to Nuclear Proteins

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 19728081
DOI: 10.1007/s10549-009-0516-9

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic contribution of GADD45A to susceptibility to sporadic and non-BRCA1/2 familial breast cancers: a systematic evaluation in Chinese populations.PMID 19728081Read ↗

Analysis of GADD45A sequence variations in French Canadian families with high risk of breast cancer.Semantic proximity Read ↗

Clinicopathological significance of GADD45 gene alterations in human familial breast carcinoma.Semantic proximity Read ↗

The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis.Semantic proximity Read ↗

Interplay between BRCA1 and GADD45A and Its Potential for Nucleotide Excision Repair in Breast Cancer PathogenesisSemantic proximity Read ↗

The stress-responsive gene GADD45G is a functional tumor suppressor, with its response to environmental stresses frequently disrupted epigenetically in multiple tumors.Semantic proximity Read ↗

Functional Evaluation of ZNF350 Missense Genetic Variants Associated with Breast Cancer Susceptibility.Semantic proximity Read ↗

A polymorphism but no mutations in the GADD45 gene in breast cancers.Semantic proximity Read ↗

RAD51 135G>C does not modify breast cancer risk in non-BRCA1/2 mutation carriers: evidence from a meta-analysis of 12 studies.Semantic proximity Read ↗

BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.Semantic proximity Read ↗

Abnormal expression of GADD45B in human colorectal carcinomaSemantic proximity Read ↗

Association of GADD45A and favorable outcome in hormone positive breast cancerSemantic proximity Read ↗

Clinicopathological significance of abnormalities in Gadd45 expression and its relationship to p53 in human pancreatic cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.