Article
Interaction between endothelial nitric oxide synthase gene polymorphisms (-786T>C, 894G>T and intron 4 a/b) and cardiovascular risk factors in acute coronary syndromes.
Archives of medical research - 1 Apr 2012
da Costa Escobar Piccoli Jacqueline, Manfredini Vanusa, Hamester Fernanda Irma, Bandinelli Josiane Bettim, Turkienicz Ilan Maltz, Chies José Artur Bogo, Peres Alessandra, Bodanese Luiz Carlos, Bogo Maurício Reis
Abstract excerpt
BACKGROUND AND AIMS: Endothelial rupture of coronary plaque can represent the pathomorphological substratum of acute coronary syndrome (ACS). Polymorphisms in the NOS3 gene (eNOS) -786T>C, 894G>T and intron 4 a/b VNTR can be associated with a higher susceptibility for ACS. The present study is focused on the investigation of the interaction of these polymorphisms and cardiovascular risk factors in 135 patients...
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