Article
NFKB1 promoter variation implicates shear-induced NOS3 gene expression and endothelial function in prehypertensives and stage I hypertensives.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2007
Park Joon-Young, Farrance Iain K G, Fenty Nicola M, Hagberg James M, Roth Stephen M, Mosser David M, Wang Min Qi, Jo Hanjoong, Okazaki Toshihiko, Brant Steven R, Brown Michael D
Abstract excerpt
In endothelial cells, NF-kappaB is an important intracellular signaling molecule by which changes in wall shear stress are transduced into the nucleus to initiate downstream endothelial nitric oxide synthase (NOS3) gene expression. We investigated whether NF-kappa light-chain gene enhancer in B cells 1 (NFKB1) promoter polymorphism ((-94)NFKB1 I/D, where I is the insertion allele and D is the deletion allele) was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.