Article
The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome.
Fertility and sterility - 1 Sept 2004
Heinonen Seppo, Korhonen Seija, Helisalmi Seppo, Koivunen Riitta, Tapanainen Juha S, Laakso Markku
Abstract excerpt
The K121Q polymorphism of the plasma cell membrane glycoprotein 1 gene was significantly associated with polycystic ovary syndrome (PCOS) susceptibility, the pooled genotype distribution (K121K vs. 121Q allele) having an odds ratio of 1.90 (95% confidence interval 1.11-3.26). This suggests that impaired insulin signaling is of etiologic importance in PCOS.
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