Article
The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.
Diabetes - 1 Oct 2005
Bacci Simonetta, Ludovico Ornella, Prudente Sabrina, Zhang Yuan-Yuan, Di Paola Rosa, Mangiacotti Davide, Rauseo Anna, Nolan David, Duffy Jill, Fini Grazia, Salvemini Lucia, Amico Cesare, Vigna Carlo, Pellegrini Fabio, Menzaghi Claudia, Doria Alessandro, Trischitta Vincenzo
Abstract excerpt
Insulin resistance (IR) is pathogenic for type 2 diabetes and coronary artery disease (CAD). The K121Q polymorphism of the ENPP1/PC-1 gene is associated with IR. Our aim was to investigate the role of the 121Q variant on the risk of type 2 diabetes and CAD. Nondiabetic control subjects (n = 638), type 2 diabetic patients without CAD (n = 535), and type 2 diabetic patients with CAD (n = 434) from Italy and the...
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