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Article

ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus.

Molecular and cellular biochemistry - 1 Nov 2017

Sumi S, Ramachandran Surya, RamanKutty V, Patel Maulin M, Anand T N, Mullasari Ajit S, Kartha C C

Abstract excerpt

Insulin resistance is associated with endothelial dysfunction and ensuing cardiovascular diseases in type 2 diabetes mellitus (T2DM) patients. ENPP1 is a key modulator of insulin signaling and its polymorphism, K121Q, increases the potency to competitively inhibit insulin receptor binding. We investigated the association of ENPP1 121Q variant with coronary artery disease (CAD) in patients with and without T2DM in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

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Share to Mutation, Missense

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Source

Identifiers

PMID: 28497367
DOI: 10.1007/s11010-017-3057-2

Genes

CAD
ENPP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus.PMID 28497367Read ↗

The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction.Semantic proximity Read ↗

The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients.Semantic proximity Read ↗

The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease.Semantic proximity Read ↗

Ethnic differences in the frequency of ENPP1/PC1 121Q genetic variant in the Dallas Heart Study cohort.Semantic proximity Read ↗

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes.Semantic proximity Read ↗

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes in North Indians.Semantic proximity Read ↗

ENPP1 K121Q (rs1044498 C > A) genetic polymorphism confers a high risk of susceptibility to coronary heart disease: A PRISMA-compliant article.Semantic proximity Read ↗

ENPP1 gene, insulin resistance and related clinical outcomes.Semantic proximity Read ↗

The K121Q polymorphism of ENPP1 and peripheral arterial disease.Semantic proximity Read ↗

PC-1 (ENPP1) K121Q polymorphism in overweight and obese type 2 diabetic coronary heart disease patients.Semantic proximity Read ↗

Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study.Semantic proximity Read ↗

The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects.Semantic proximity Read ↗

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