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Article

Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.

Diabetes, obesity & metabolism - 1 Nov 2006

Wan C, Zhang T, Wang B, Han Y, Zhang C, Zhang Y, Gong H, Jin F, Wang L

Abstract excerpt

BACKGROUND: Obesity is considered to be a multifactorial trait resulting from the combined influence of genetic and environmental determinants. Insulin resistance plays an important role in the development of obesity. Plasma-cell membrane differentiation antigene-1 (PC-1) inhibits insulin receptor signalling when overexpressed and thus causes insulin resistance. PC-1 gene polymorphism might be associated with...

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Identifiers

PMID: 17026496
DOI: 10.1111/j.1463-1326.2006.00583.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Obesity risk associated with the K121Q polymorphism of the glycoprotein PC-1 gene.PMID 17026496Read ↗

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.Semantic proximity Read ↗

K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population.Semantic proximity Read ↗

ENPP1/PC-1 gene K121Q polymorphism is associated with obesity in European adult populations: evidence from a meta-analysis involving 24,324 subjects.Semantic proximity Read ↗

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.Semantic proximity Read ↗

The K121Q polymorphism of the PC-1 gene is associated with insulin resistance but not with dyslipidemia.Semantic proximity Read ↗

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.Semantic proximity Read ↗

Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.Semantic proximity Read ↗

Association of ENPP1 (PC-1) K121Q polymorphism with obesity-related parameters in subjects with metabolic syndrome.Semantic proximity Read ↗

The Q121/Q121 genotype of ENPP1/PC-1 is associated with lower BMI in non-diabetic whites.Semantic proximity Read ↗

The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome.Semantic proximity Read ↗

The association of PC-1 (ENPP1) K121Q polymorphism with metabolic syndrome in patients with coronary heart disease.Semantic proximity Read ↗

The PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic and is associated with type 2 diabetes.Semantic proximity Read ↗

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