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Article

Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.

The Journal of clinical endocrinology and metabolism - 1 Dec 2003

Abate Nicola, Carulli Lucia, Cabo-Chan Alberto, Chandalia Manisha, Snell Peter G, Grundy Scott M

Abstract excerpt

Genetic susceptibility may be responsible for high prevalence of insulin resistance in Asian Indians. This study was carried out in samples of local Asian Indians and Caucasians to determine whether plasma cell membrane glycoprotein (PC)-1 K121Q and insulin receptor substrate-1 (IRS-1) G972A poly...

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Source

Identifiers

PMID: 14671192
DOI: 10.1210/jc.2003-030453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14671192-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Genetic polymorphism PC-1 K121Q and ethnic susceptibility to insulin resistance.PMID 14671192Read ↗

ENPP1/PC-1 K121Q polymorphism and genetic susceptibility to type 2 diabetes.Semantic proximity Read ↗

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The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome.Semantic proximity Read ↗

The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance.Semantic proximity Read ↗

K121Q PC-1 gene polymorphism is not associated with insulin resistance in a Spanish population.Semantic proximity Read ↗

The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121).Semantic proximity Read ↗

ENPP1 121Q functional variant enhances susceptibility to coronary artery disease in South Indian patients with type 2 diabetes mellitus.Semantic proximity Read ↗

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Role of the ENPP1 K121Q polymorphism in glucose homeostasis.Semantic proximity Read ↗

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