Article
The relationship between the epidermal growth factor (EGF) 5'UTR variant A61G and melanoma/nevus susceptibility.
The Journal of investigative dermatology - 1 Oct 2004
Randerson-Moor J A, Gaut R, Turner F, Whitaker L, Barrett J H, Silva I dos Santos, Swerdlow A, Bishop D T, Bishop J A Newton
Abstract excerpt
The inheritance of a G allele in position 61 in the 5'UTR of the epidermal growth factor (EGF) gene has been reported to increase melanoma susceptibility, a finding we have investigated in this study. The most potent phenotypic risk factor for melanoma is the atypical mole syndrome (AMS) phenotype. Our hypothesis is that the AMS is genetically determined and that nevus genes are also low penetrance melanoma...
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