Article
An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype.
The Journal of investigative dermatology - 1 Feb 2004
Bertram Chandra Gooptu, Gaut Rupert M, Barrett Jennifer H, Randerson-Moor Juliette, Whitaker Linda, Turner Faye, Bataille Veronique, dos Santos Silva Isabel, Swerdlow Anthony J, Bishop D Timothy, Newton Bishop Julia A
Abstract excerpt
Inheritance of the T allele in exon 7 (position 18067) of the DNA repair gene XRCC3 has been reported to be associated with susceptibility to melanoma in a study from Oxford. We report a study in which an attempt was made to confirm this association in a similar population. The most potent risk factor for melanoma in the general population is a phenotype characterized by the presence of multiple melanocytic nevi:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.