Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding region.

doi:10.1002/j.1460-2075.1992.tb05090.x

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Article

Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding region.

The EMBO journal - 1 Feb 1992

Pollard S R, Rosa M D, Rosa J J, Wiley D C

Abstract excerpt

The envelope glycoprotein, gp120, of human immunodeficiency virus type 1 (HIV-1) binds the cellular protein CD4 with high affinity. By deletion we show that 62 N- and 20 C-terminal residues along with the V1, V2 and V3 variable regions of gp 120 are unnecessary for CD4 binding. A 287 residue vari...

Topics

Animals
Binding Sites
CD4 Antigens
Cell Line
Chromosome Deletion
Disulfides
Genetic Variation
HIV Envelope Protein gp120
HIV-1
Kinetics
Models, Structural
Plasmids
Polymerase Chain Reaction
Protein Conformation
Protein Engineering
Transfection

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