Article
A region in domain 1 of CD4 distinct from the primary gp120 binding site is involved in HIV infection and virus-mediated fusion.
The Journal of biological chemistry - 25 Mar 1991
Truneh A, Buck D, Cassatt D R, Juszczak R, Kassis S, Ryu S E, Healey D, Sweet R, Sattentau Q
Abstract excerpt
The high affinity binding site for human immunodeficiency virus (HIV) envelope glycoprotein gp120 resides within the amino-terminal domain (D1) of CD4. Mutational and antibody epitope analyses have implicated the region encompassing residues 40-60 in D1 as the primary binding site for gp120. Outside of this region, a single residue substitution at position 87 abrogates syncytium formation without affecting gp120...
Topics
- Antibodies, Monoclonal
- CD4 Antigens
- Epitopes
- Giant Cells
- HIV Envelope Protein gp120
- HIV Infections
- Humans
- Models, Molecular
- Mutation
- Precipitin Tests
- Protein Conformation