Article
Cell-line-induced mutation of the rotavirus genome alters expression of an IRF3-interacting protein.
The EMBO journal - 13 Oct 2004
Kearney Karen, Chen Dayue, Taraporewala Zenobia F, Vende Patrice, Hoshino Yasutaka, Tortorici Maria Alejandra, Barro Mario, Patton John T
Abstract excerpt
Rotavirus, a cause of severe gastroenteritis, contains a segmented double-stranded (ds)RNA genome that replicates using viral mRNAs as templates. The highly conserved 3'-consensus sequence (3'CS), UGUGACC, of the mRNAs promotes dsRNA synthesis and enhances translation. We have found that the 3'CS of the gene (g5) encoding NSP1, an antagonist of interferon signaling, undergoes rapid mutation when rhesus rotavirus...
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