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Diversity of Interferon Antagonist Activities Mediated by NSP1 Proteins of Different Rotavirus Strains

22 Dec 2010

Abstract excerpt

Studies involving limited numbers of rotavirus (RV) strains have shown that the viral gene 5 product, NSP1, can antagonize beta interferon (IFN-β) expression by inducing the degradation of IFN-regulatory factors (IRFs) (IRF3, IRF5, and IRF7) or a component of the E3 ubiquitin ligase complex responsible for activating NF-κB (β-transducin repeat-containing protein [β-TrCP]). To gain a broader perspective of NSP1...

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PMID: 21177809
DOI: 10.1128/jvi.01801-10

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