Article
Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells.
Biochemical and biophysical research communications - 24 Jul 2009
Li Qinxi, Ye Zhiyun, Wen Jun, Ma Lin, He Ying, Lian Guili, Wang Zhen, Wei Luyao, Wu Di, Jiang Bin
Abstract excerpt
The tumor necrosis factor (TNF) can induce apoptosis in many cells including MCF-7 cells. To identify the genes responsible for TNF-induced apoptosis, we generated a series of TNF-resistant MCF-7 cell lines by employing retrovirus insertion-mediated random mutagenesis. In one of the resistant lin...
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