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Article

Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2003

Koike Mio, Yamanaka Yoshitaka, Inoue Masaru, Tanaka Hiroyuki, Nishimura Riko, Seino Yoshiki

Abstract excerpt

UNLABELLED: An activated mutation in the FGFR3 gene causes ACH. To examine the effects of IGF-1, which is an important mediator of GH, on apoptosis, we analyzed a chondrogenic cell line expressing the FGFR3 mutants. Our findings that IGF-1 prevented the apoptosis through PI3K and MAPK pathways may explain how GH treatment improves the disturbed bone growth in ACH. INTRODUCTION: Achondroplasia (ACH), which is...

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Source

Identifiers

PMID: 14606518
DOI: 10.1359/jbmr.2003.18.11.2043

Genes

FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insulin-like growth factor-1 rescues the mutated FGF receptor 3 (G380R) expressing ATDC5 cells from apoptosis through phosphatidylinositol 3-kinase and MAPK.PMID 14606518Read ↗

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