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Article

Trps1 plays a pivotal role downstream of Gdf5 signaling in promoting chondrogenesis and apoptosis of ATDC5 cells.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2008

Itoh Shunji, Kanno Seiji, Gai Zhibo, Suemoto Hiroki, Kawakatsu Motohisa, Tanishima Hiroyuki, Morimoto Yoshifumi, Nishioka Katsuhiro, Hatamura Ikuji, Yoshida Munehito, Muragaki Yasuteru

Abstract excerpt

Tricho-rhino-phalangeal syndrome (TRPS) is an autosomal dominant skeletal disorder caused by mutations of TRPS1. Based on the similar expression patterns of Trps1 and Gdf5, we hypothesized a possible functional interaction between these two molecules. Using a chondrogenic cell line (ATDC5), we investigated the association of Gdf5-mediated signaling pathways with Trps1 and the phenotypic changes of ATDC5 cells due...

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Source

Identifiers

PMID: 18363966
DOI: 10.1111/j.1365-2443.2008.01170.x

Genes

TRPS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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