Article
Fcgamma receptor IIA genotype and susceptibility to P. aeruginosa infection in patients with cystic fibrosis.
European journal of human genetics : EJHG - 1 Jan 2005
De Rose Virginia, Arduino Carlo, Cappello Nazario, Piana Rita, Salmin Paola, Bardessono Marco, Goia Manuela, Padoan Rita, Bignamini Elisabetta, Costantini Diana, Pizzamiglio Giovanna, Bennato Veronica, Colombo Carla, Giunta Annamaria, Piazza Alberto
Abstract excerpt
It has been suggested that genes other than CFTR could modulate the severity of lung disease in cystic fibrosis (CF). Neutrophil Fcgamma receptor II (FcgammaRII) is involved in host defense against microorganisms and in inflammatory response. We evaluated the association between genetic variability of this gene and both airway infection with Pseudomonas aeruginosa and severity of lung disease in patients with CF....
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