Article
CARD15 gene mutations in periodontitis.
Journal of clinical periodontology - 1 Oct 2004
Laine M L, Murillo L S, Morré S A, Winkel E G, Peña A S, van Winkelhoff A J
Abstract excerpt
OBJECTIVES: The CARD15 gene encodes the Nod2 protein, which is involved in intracellular recognition of bacterial products like peptidoglycan, activates inflammation and regulates apoptosis through nuclear factor-kappa B, a transcription factor that plays a central role in the innate immunity. Two functional mutations, an insertion mutation at nucleotide 3020 (3020insC) and a missense mutation C2104T in the...
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