Article
ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.
Cell cycle (Georgetown, Tex.) - 1 Dec 2004
Davalos Albert R, Kaminker Patrick, Hansen Rhonda K, Campisi Judith
Abstract excerpt
The BLM helicase, a deficiency that markedly increases cancer incidence in humans, is required for optimal repair during DNA replication. We show that BLM rapidly moves from PML nuclear bodies to damaged replication forks, returning to PML bodies several hours later, owing to activities of the DNA damage response kinases ATR and ATM, respectively. Immunofluorescence and cellular fractionation demonstrate that BLM...
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