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Article

Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1.

Developmental cell - 1 Sept 2004

Nakaya Yukiko, Kuroda Shinya, Katagiri Yuji T, Kaibuchi Kozo, Takahashi Yoshiko

Abstract excerpt

Mesenchymal-epithelial transitions (MET) are crucial for vertebrate organogenesis. The roles of Rho family GTPases in such processes during actual development remain largely unknown. By electroporating genes into chick presomitic mesenchymal cells, we demonstrate that Cdc42 and Rac1 play important and different roles in the MET that generates the vertebrate somites. Presomitic mesenchymal cells, which normally...

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Source

Identifiers

PMID: 15363416
DOI: 10.1016/j.devcel.2004.08.003

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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