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Article

Bmp7 Functions via a Polarity Mechanism to Promote Cloacal Septation

13 Jan 2012

Abstract excerpt

BACKGROUND: During normal development in human and other placental mammals, the embryonic cloacal cavity separates along the axial longitudinal plane to give rise to the urethral system, ventrally, and the rectum, dorsally. Defects in cloacal development are very common and present clinically as a rectourethral fistula in about 1 in 5,000 live human births. Yet, the cellular mechanisms of cloacal septation remain...

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PMID: 22253716
DOI: 10.1371/journal.pone.0029372

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