Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway.

Proceedings of the National Academy of Sciences of the United States of America - 28 Jul 2009

Buchon Nicolas, Poidevin Mickael, Kwon Hyun-Mi, Guillou Aurélien, Sottas Valentin, Lee Bok-Luel, Lemaitre Bruno

Abstract excerpt

The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine proteases, which are activated by secreted pattern-recognition receptors. Here, we demonstrate the essential role of ModSP, a modular serine protease, in the activation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fungi
Share to Gram-Positive Bacteria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Host-Pathogen Interactions

Share to Receptors, Pattern Recognition

Share to Serine Endopeptidases

Share to Spodoptera

Share to Toll-Like Receptors

Source

Open in PubMed Open full text

Identifiers

PMID: 19590012
DOI: 10.1073/pnas.0901924106
PMCID: PMC2718337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A single modular serine protease integrates signals from pattern-recognition receptors upstream of the Drosophila Toll pathway.PMID 19590012Read ↗

Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein.Semantic proximity Read ↗

The Circulating Protease Persephone Is an Immune Sensor for Microbial Proteolytic Activities Upstream of the Drosophila Toll PathwaySemantic proximity Read ↗

Peptidoglycan recognition proteins: on and off switches for innate immunitySemantic proximity Read ↗

Spätzle-Processing Enzyme-independent Activation of the Toll Pathway in Drosophila Innate Immunity.Semantic proximity Read ↗

The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.Semantic proximity Read ↗

Drosophila caspases as guardians of host-microbe interactionsSemantic proximity Read ↗

Activation of Drosophila Toll during fungal infection by a blood serine protease.Semantic proximity Read ↗

CATERPILLER (NLR) family members as positive and negative regulators of inflammatory responses.Semantic proximity Read ↗

Inflammasomes in Teleosts: Structures and Mechanisms That Induce Pyroptosis during Bacterial InfectionSemantic proximity Read ↗

The subversion of toll-like receptor signaling by bacterial and viral proteases during the development of infectious diseasesSemantic proximity Read ↗

Persephone/Spätzle pathogen sensors mediate the activation of Toll receptor signaling in response to endogenous danger signals in apoptosis-deficient Drosophila.Semantic proximity Read ↗

Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.