Article
Advanced cardiac morphogenesis does not require heart tube fusion.
Science (New York, N.Y.) - 10 Sept 2004
Li Shanru, Zhou Deying, Lu Min Min, Morrisey Edward E
Abstract excerpt
The bilateral cardiac mesoderm migrates from the lateral region of the embryo to the ventral midline, where it fuses to form the primitive heart tube. It is generally accepted that migration and fusion are essential for subsequent stages of cardiac morphogenesis. We present evidence that, in Foxp4 mutant embryonic mice, each bilateral heart-forming region is capable of developing into a highly differentiated...
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