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Article

TNF-alpha induces proliferation or apoptosis in human saphenous vein smooth muscle cells depending on phenotype.

American journal of physiology. Heart and circulatory physiology - 1 Jan 2005

Wang Zhongbiao, Rao Pulipaka J, Castresana Manuel R, Newman Walter H

Abstract excerpt

Tumor necrosis factor (TNF)-alpha is implicated in development of restenotic and atherosclerotic vascular lesions, which are pathological processes involving both proliferation and apoptosis of vascular smooth muscle cells (VSMCs). Human VSMCs were recently found to contain heterogeneous subpopulations. We therefore examined whether TNF has different effects on distinct subpopulations of VSMCs. With the use of...

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Source

Identifiers

PMID: 15358608
DOI: 10.1152/ajpheart.00165.2004

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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