Article
A method to isolate morphologically distinct clones of smooth muscle cells from human saphenous vein.
Methods in cell science : an official journal of the Society for In Vitro Biology - 1 Jan 2002
Wang Zhongbiao, Rao Pulipaka J, Castresana Manuel R, Newman Walter H
Abstract excerpt
The monoclonal theory of atherosclerosis postulates that a certain subpopulation of vascular smooth muscle cells (VSMC) is selectively expanded in response to pathological stimuli thereby contributing to the formation of atherosclerotic plaques. VSMC cloning experiments will be important in characterizing the phenotypic composition of VSMC in atherosclerotic plaques. However, the difficulty in cloning human VSMC...
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