Article
Angiotensin II induces phenotype-dependent apoptosis in vascular smooth muscle cells.
Hypertension (Dallas, Tex. : 1979) - 1 Dec 2001
Bascands J L, Girolami J P, Troly M, Escargueil-Blanc I, Nazzal D, Salvayre R, Blaes N
Abstract excerpt
Angiotensin II regulates vascular structure through growth and apoptosis, with implications in pathophysiology. Subtypes of vascular smooth muscle cells with specific morphology, growth, or apoptotic features have been isolated. Here, we investigated the effects of angiotensin II on apoptosis of 2 morphologically different rat aortic smooth muscle cell phenotypes. Spindle and epithelioid cell lines cultured under...
Topics
- Angiotensin II
- Animals
- Apoptosis
- Calcium
- Cells, Cultured
- Dose-Response Relationship, Drug
- Muscle, Smooth, Vascular
- NG-Nitroarginine Methyl Ester
- Nitric Oxide
- Phenotype
- Rats
- Rats, Wistar
- Receptor, Angiotensin, Type 1
- Receptors, Angiotensin