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Article

p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.

The Journal of biological chemistry - 26 Nov 2004

Woods Yvonne L, Xirodimas Dimitris P, Prescott Alan R, Sparks Alison, Lane David P, Saville Mark K

Abstract excerpt

Here we demonstrate a novel p53-independent interaction between the nucleolar tumor suppressors, p14 Arf and Werners helicase (WRN). Binding of p14 Arf to WRN is multivalent and resembles the binding of p14 Arf to Mdm2. Residues 2-14 and 82-101 of p14 Arf and residues in the central region and C terminus of WRN have particular importance for binding. p14 Arf promotes small ubiquitin-like modifier (SUMO)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15355988
DOI: 10.1074/jbc.M405414200

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase.PMID 15355988Read ↗

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