Article
[Pharmacogenetics or the promise of a personalized medicine: variability in drug metabolism and transport].
Annales de biologie clinique - 1 Jan 2000
Allorge D, Loriot M-A
Abstract excerpt
There is much variability in the manner individuals respond to drugs, such that the management of some drugs is problematic. In France, the incidence of hospital admissions related to adverse drug reactions is estimated to be 3.2 %, at an annual cost of over 300 millions euros. Genetic factors affecting the pharmacokinetics and pharmacodynamics of drugs partly explain interindividual variability in drug response....
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