Article
Pharmacogenetics/genomics and personalized medicine.
Human molecular genetics - 15 Oct 2005
Sadée Wolfgang, Dai Zunyan
Abstract excerpt
Despite the marked advances in drug therapy, some patients do not respond favorably or suffer severe adverse drug effects. Pharmacogenetic studies have shown that polymorphisms of drug metabolizing enzymes, transporters and receptors contribute to variable drug response. Owing to the complexity of drug actions, a broader genomics approach aims at finding new drug targets and optimizing therapy for the individual...
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