Article
Implications of pharmacogenetics for individualizing drug treatment and for study design.
Journal of molecular medicine (Berlin, Germany) - 1 Mar 2003
Meisel Christian, Gerloff Thomas, Kirchheiner Julia, Mrozikiewicz Przemyslaw M, Niewinski Przemyslaw, Brockmöller Jürgen, Roots Ivar
Abstract excerpt
Adverse drug reactions and ineffective drug treatment are responsible for a large health care burden. Considerable variability in drug response makes the prediction of the individual reaction difficult. Pharmacogenetics can help to individualize drug treatment in accordance with the genetic make-up of the patient. Drug response is best understood as a complex interplay between pharmacokinetics, pharmacodynamics,...
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