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[Effect of SHIP mutation on invasion and migration of K562 leukemia cells].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Jan 2012

Liu Xiao-jun, Yang Lin, Wen Shu-peng, Yao Li, Yang Jing-ci, Luo Jian-min

Abstract excerpt

OBJECTIVE: To explore the effect of mutation in PxxP domain of SHIP on migration and invasion of leukemia cells and its mechanism. METHODS: The lentiviral vector mediated wild type SHIP (wtSHIP) and mutant SHIP (muSHIP) plasmids were transfected into K562 cells through gene transfection techniques. Expression of SHIP at mRNA and protein level was detected by real-time PCR and Western blot, respectively. Transwell...

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PMID: 22575191

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