Article
A soluble factor released by CD8+CD57+ lymphocytes from bone marrow transplanted patients inhibits cell-mediated cytolysis.
Blood - 15 May 1991
Autran B, Leblond V, Sadat-Sowti B, Lefranc E, Got P, Sutton L, Binet J L, Debre P
Abstract excerpt
We report a new inhibitory activity of CD8+CD57+ peripheral blood lymphocytes from allo-bone marrow transplant patients. Positively selected CD8+CD57+ lymphocytes act as potent inhibitors of allospecific cytolytic T lymphocyte and lymphokine activated killer cell cytolytic activities. These suppr...
Topics
- Antigens, Differentiation, T-Lymphocyte
- Bone Marrow Transplantation
- CD57 Antigens
- CD8 Antigens
- Cell Division
- Centrifugation
- Chromatography, Affinity
- Fluorescent Antibody Technique
- Glycosylation
- Humans
- Immunity, Cellular
- Killer Cells, Lymphokine-Activated
- Killer Cells, Natural
- Lymphocytes
- Molecular Weight
- Phenotype
- Proteins
- T-Lymphocytes, Cytotoxic