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Article

Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice.

The Journal of experimental medicine - 6 Sept 2004

Karakousis Petros C, Yoshimatsu Tetsuyuki, Lamichhane Gyanu, Woolwine Samuel C, Nuermberger Eric L, Grosset Jacques, Bishai William R

Abstract excerpt

Mycobacterium tuberculosis residing within pulmonary granulomas and cavities represents an important reservoir of persistent organisms during human latent tuberculosis infection. We present a novel in vivo model of tuberculosis involving the encapsulation of bacilli in semidiffusible hollow fibers that are implanted subcutaneously into mice. Granulomatous lesions develop around these hollow fibers, and in this...

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Identifiers

PMID: 15353557
DOI: 10.1084/jem.20040646
PMCID: PMC2212740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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