Article
Human mesenchymal stem cell based intracellular dormancy model of Mycobacterium tuberculosis.
Microbes and infection - 1 Oct 2020
Singh Vipul K, Mishra Abhishek, Bark Steven, Mani Arunmani, Subbian Selvakumar, Hunter Robert L, Jagannath Chinnaswamy, Khan Arshad
Abstract excerpt
Understanding the biology of the tuberculosis pathogen during dormant asymptomatic infection, called latent tuberculosis is crucial to decipher a resilient therapeutic strategy for the disease. Recent discoveries exhibiting presence of pathogen's DNA and bacilli in mesenchymal stem cells (MSCs) of human and mouse despite completion of antitubercular therapy, indicates that these specific cells could be one of the...
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