Article
XBP-1 increases ERalpha transcriptional activity through regulation of large-scale chromatin unfolding.
Biochemical and biophysical research communications - 8 Oct 2004
Fang Yan, Yan Jinghua, Ding Lihua, Liu Yufei, Zhu Jianhua, Huang Cuifen, Zhao Haiquan, Lu Qiujun, Zhang Xuemin, Yang Xiao, Ye Qinong
Abstract excerpt
Human X box binding protein 1 (XBP-1) is a transcription factor essential for hepatocyte growth, the differentiation of plasma cells, and the unfolded protein response. Recently, we have demonstrated that two forms of XBP-1, XBP-1S, and XBP-1U, enhance estrogen receptor alpha (ERalpha)-dependent transcriptional activity in a ligand-independent manner. However, how XBP-1S and XBP-1U regulate ERalpha...
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