Article
BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations.
The Journal of cell biology - 10 Dec 2001
Ye Q, Hu Y F, Zhong H, Nye A C, Belmont A S, Li R
Abstract excerpt
The breast cancer susceptibility gene BRCA1 encodes a protein that has been implicated in multiple nuclear functions, including transcription and DNA repair. The multifunctional nature of BRCA1 has raised the possibility that the polypeptide may regulate various nuclear processes via a common underlying mechanism such as chromatin remodeling. However, to date, no direct evidence exists in mammalian cells for...
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