Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of large-scale chromatin unfolding by Smad4.

Biochemical and biophysical research communications - 5 Mar 2004

Yan Jinghua, Fang Yan, Ding Lihua, Zhu Jianhua, Lu Qiujun, Huang Cuifen, Yang Xiao, Ye Qinong

Abstract excerpt

The tumor suppressor Smad4 plays a critical role in the transforming growth factor-beta (TGF-beta signaling pathway. Smad4 is an essential component of transcriptional complexes mediating the activation of Smad-dependent target genes. However, how Smad4 regulates various chromosomal events remains unknown. Here, we report that Smad4 induces large-scale chromatin unfolding by targeting Smad4 to an amplified, lac...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Chromatin
Share to Luciferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Denaturation

Share to Protein Folding

Share to Smad4 Protein

Share to Transcriptional Activation

Share to Transforming Growth Factor beta

Source

Identifiers

PMID: 14766211
DOI: 10.1016/j.bbrc.2004.01.051

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of large-scale chromatin unfolding by Smad4.PMID 14766211Read ↗

Tumor-derived C-terminal mutations of Smad4 with decreased DNA binding activity and enhanced intramolecular interactionSemantic proximity Read ↗

Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4Semantic proximity Read ↗

Human pescadillo induces large-scale chromatin unfolding.Semantic proximity Read ↗

SMAD4 nanobodies as tools for investigating SMAD structures and modulating SMAD functionSemantic proximity Read ↗

Structural determinants of Smad function in TGF-β signaling.Semantic proximity Read ↗

A novel mouse Smad4 mutation reduces protein stability and wild-type protein levels.Semantic proximity Read ↗

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.Semantic proximity Read ↗

The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation DomainSemantic proximity Read ↗

A structural basis for mutational inactivation of the tumour suppressor Smad4Semantic proximity Read ↗

Colorectal Cancer-Associated Smad4 R361 Hotspot Mutations Boost Wnt/β-Catenin Signaling through Enhanced Smad4-LEF1 Binding.Semantic proximity Read ↗

Role of Smad4 (DPC4) inactivation in human cancer.Semantic proximity Read ↗

SMAD4 Regulates Cell Motility through Transcription of N-Cadherin in Human Pancreatic Ductal EpitheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.