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[Pharmacological chaperones: a potential therapeutic treatment for conformational diseases].

Medecine sciences : M/S - 1 Jan 2000

Mendre Christiane, Mouillac Bernard

Abstract excerpt

Many genetic and neurodegenerative diseases in humans result from protein misfolding and/or aggregation. These diseases are named conformational diseases. As a result, the misfolded non functional proteins are rejected and misrouted by the cellular quality control system, and cannot play their endogenous physiological roles. Specific compounds (ligands, substrates or inhibitors) known as pharmacological...

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Identifiers

PMID: 20619166
DOI: 10.1051/medsci/2010266-7627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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