Article
Lack of evidence for predictive and prognostic value of cyclin D1 gene polymorphism CCND1 G870A for oral squamous cell carcinoma.
Anticancer research - 1 Jan 2014
Atac Artun, Riecke Björn, Assaf Alexandre T, Gröbe Alexander, Friedrich Reinhard E, Heiland Max, Izbicki Jakob R, Kluwe Lan, Blessmann Marco
Abstract excerpt
BACKGROUND/AIM: Cyclin D1 gene (CCND1) has a G to A polymorphism at the splice donor site of exon 4, position 870. The A allele codes for a truncated variant, cyclin D1b, which may have higher transforming activity. Data regarding the predictive and prognostic value of the CCND1 G870A polymorphism in tumors are controversial. We aimed to examine this polymorphism in patients with oral carcinoma. MATERIALS AND...
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