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Article

Generalized brain and skin proteasome inhibition in Huntington's disease.

Annals of neurology - 1 Sept 2004

Seo Hyemyung, Sonntag Kai-Christian, Isacson Ole

Abstract excerpt

Mutated intracellular huntingtin is widely expressed in tissues of Huntington's disease (HD) patients. Intraneuronal nuclear protein aggregates of mutant huntingtin are present in HD brains, suggesting a dysfunction of the ubiquitin proteasome system (UPS). Because many cells and tissues can cope with the abnormal gene effects while others dysfunction and die, we determined gene-induced effects and considered the...

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PMID: 15349858
DOI: 10.1002/ana.20207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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