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Article

Ubiquitin-proteasome system alterations in a striatal cell model of Huntington's disease.

Journal of neuroscience research - 1 Jun 2007

Hunter Jesse M, Lesort Mathieu, Johnson Gail V W

Abstract excerpt

Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligomers, or ag...

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Identifiers

PMID: 17455294
DOI: 10.1002/jnr.21287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17455294-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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