Improvement of pCOR plasmid copy number for pharmaceutical applications.

doi:10.1007/s00253-004-1729-9

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Article

Improvement of pCOR plasmid copy number for pharmaceutical applications.

Applied microbiology and biotechnology - 1 Mar 2005

Soubrier F, Laborderie B, Cameron B

Abstract excerpt

Production of pharmaceutical-grade plasmid DNA is becoming important as the demand for clinical batches is steadily growing. pCOR plasmids have been specifically designed and used for gene delivery into humans, and have been produced by high cell-density fermentation with a yield of 100 mg/l. This yield could probably be increased as long as the release specifications of bulk plasmid remain the same, particularly...

Topics

DNA Helicases
DNA Replication
DNA-Binding Proteins
Escherichia coli
Genes, Bacterial
Genetic Vectors
Mutation
Plasmids
Trans-Activators

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Open in PubMed

Identifiers

PMID: 15349701
DOI: 10.1007/s00253-004-1729-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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