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Article

Isolation and characterization of pLS1 plasmid mutants with increased copy numbers.

FEMS microbiology letters - 15 Jun 1996

Acebo P, Alda M T, Espinosa M, del Solar G

Abstract excerpt

Streptococcus pneumoniae genetic systems designed for isolation of plasmid mutants with copy-up phenotypes have been developed. The target plasmids have the pLS1 replicon, and two different strategies have been followed: (i) selection of clones exhibiting augmented resistance to antibiotics, or (ii) obligatory co-existence of incompatible plasmids. We have isolated 23 plasmid mutants exhibiting increased number...

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PMID: 8666205
DOI: 10.1111/j.1574-6968.1996.tb08319.x

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