Article
Induction of tolerance in quadruple chimeric mice.
Stem cells (Dayton, Ohio) - 1 Jan 2004
Fan Tian-Xue, Hisha Hiroko, Jin Tie-Nan, Sugiura Kikuya, Inaba Muneo, Yang Guo-Xiang, Li Qing, Wang Xiao-Li, Song Chang-Ye, Cui Yun-Ze, Li Qiang, Zhang Yuming, Zhang Xiao-Guang, Fan Hong-Xue, Ikehara Susumu
Abstract excerpt
Human cord blood (CB) contains hematopoietic stem cells and progenitors. Because the major limitation to a widespread use of CB for transplantation lies in its limited volume, it is necessary to combine the CB from several donors. In this study, we show that lethally irradiated mice can be reconstituted with the injection of a mixture of T cell-depleted bone marrow cells (BMCs; total, 3 x 10(6)) obtained from...
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