Article
Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation.
Transplantation - 15 Apr 2000
Hale D A, Gottschalk R, Umemura A, Maki T, Monaco A P
Abstract excerpt
BACKGROUND: Induction of tolerance to organ transplants will increase graft survival and decrease patient mortality and morbidity. Radiation-induced cytoreduction/ablation followed by donor hematopoietic cell reconstitution has been the most consistently successful approach to experimental tolerance induction. However, reluctance of clinicians to expose recipients to radiation has hampered its clinical...
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